Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. one of two or more homologous gene sequences found in different species

Etymologies

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Examples

  • AKAP5, also referred to as AKAP150 in rodents, is an orthologue of human AKAP79 and bovine AKAP75 and is highly expressed in brain

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  • LRP5, together with LRP6, is the human orthologue of the

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  • In line with this reasoning, the closest human orthologue of Xnf7 - TRIM69 (42% identity to Xnf7) - was not reported for MSP

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  • Xenopus orthologue of the C. elegans protein Smu-1 suppressor of mec-8 and unc-52, which is believed to regulate the alternative splicing of pre-mRNAs

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  • Furthermore, we showed that transfection of HeLa cells with siRNAs, corresponding to the human orthologue of Mgc81475 dramatically perturbs spindle formation in HeLa cells.

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  • Mgc68500's closest orthologue in man is intracellular hyaluronan-binding protein IHBP4 (HABP4) [68], reminding another hyaluronan-related protein, RHAMM, which participates in Ran-dependent spindle assembly

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  • Knocking-down the human orthologue of Mgc81475 clearly implicated this protein in the microtubule stabilization in mitosis.

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  • We found that the effect of RNAi on the mitotic index was most prominent in the case of the two siRNAs directed against the human orthologue of Mgc81475 (huMgc81475).

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  • Mitotic index in HeLa cells treated with siRNA against the human orthologue of Mgc81475.

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  • Human orthologue entry is used for the search in the "GeneCards" database.

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