from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any abnormal or defective development of a bone
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. defective bone development; usually attributable to renal disease or to disturbances in calcium and phosphorus metabolism
Phosphate retention and the resulting hyperphosphatemia in patients with ESRD on dialysis are usually associated with secondary hyperparathyroidism, renal osteodystrophy, soft tissue mineralization and the progression of renal failure.
If not treated, hyperphosphatemia could lead to serious or fatal complications such as bone deformation (renal osteodystrophy), coronary calcification, heart disease, stroke and cardiovascular diseases which account for about half of the causes of death in the ESRD population.
Lack of these elements causes osteoporosis, osteomalacia, osteodystrophy and other related health complications.
Without effective treatment, hyperphosphatemia may lead to renal osteodystrophy, a collection of bone diseases characterized by bone pain, brittle bones, skeletal deformities and fractures.
This hyperphosphatemia is associated with secondary hyperparathyroidism, renal osteodystrophy, soft tissue mineralization, and progression of renal failure.
In hypertrophic osteodystrophy, there is an issue with the long aspect of the bones causing trouble with the growth plate.
This loss of bone results from a combination of factors that include pre-existing renal osteodystrophy, immunosuppressive therapy, and the effects of chronically reduced renal function after transplantation.