osteoprotegerin love



from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A cytokine that can inhibit the production of osteoclasts.


From osteo- (“bone”) + protegere (“to protect”) + -in (“compound-forming suffix”). (Wiktionary)


  • They studied a protein called osteoprotegerin (OPG), which in healthy people plays a crucial role in maintaining bone health by controlling the rate at which bone tissue is removed.

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  • Chen Y, Stephens O, Brown N, Chen B, et al. (2008) Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma.

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  • Bu G, Lu W, Liu CC, Selander K, Yoneda T, et al. (2008) Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases.

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  • Jin Q, Cirelli JA, Park CH, Sugai JV, Taba M Jr, et al. (2007) RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis.

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  • Indeed, in a variety of murine models, vascular calcification develops in the absence of overt atherosclerosis. 3 Furthermore, osteoprotegerin has been reported to inhibit vascular calcification without affecting atherosclerosis,

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  • The role of osteoprotegerin and receptor activator of nuclear factor kappaB ligand in the pathogenesis and treatment of rheumatoid arthritis.

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  • Ziolkowska M, Kurowska M, Radzikowska A, Luszczykiewicz G, Wiland P, Dziewczopolski W, et al. High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor alpha treatment.

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  • Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.

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  • Anti TNF therapy induces synovial osteoprotegerin expression in rheumatoid arthritis.

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  • Skoumal M, Kolarz G, Woloszczuk W, Hawa G, Klingler A. Serum osteoprotegerin but not receptor activator of NF-kappaB ligand correlates with Larsen score in rheumatoid arthritis.

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