ovalocytosis

197 Called ovalocytosis, this disorder: Jarolim et al., 1991; Schofield et al., 1992.

Parasite Rex

Called ovalocytosis, this disorder follows the same genetic rules as sickle cell anemia: it’s mild if a person only inherits the defective gene from one parent, but severe if both parents pass it on—so severe, in fact, that a baby with two genes will almost always die before it’s born.

Parasite Rex

The RBCs from patients with HS, in addition to hereditary pyropoikilocytosis (HPP) and south east asian ovalocytosis (SAO) show reduced fluorescence.

Immunology Lab

But ovalocytosis also makes red blood cells less hospitable to Plasmodium.

Parasite Rex

Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis.

Parasite Rex

Stunting the growth of parasites—whether by thalassemia, ovalocytosis, or sickle cell anemia—gives the immune system more time to get beyond Plasmodium’s evasions, recognize it, and mount a response.

Parasite Rex