Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun An
inhibitor ofxanthine oxidase .
Etymologies
Sorry, no etymologies found.
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Examples
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Although allopurinol itself has a short half-life in plasma (about 90 to 120 minutes) oxypurinol has a very long half-life, 18 to
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Consequently, steady-state levels of oxypurinol are achieved in a few days, and uric acid concentrations can be maintained at the desired level by proper dose-adjustment
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This is due to the fact that oxypurinol is reabsorbed in the proximal tubule of the kidney (80).
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Allopurinol is not only a potent competitive inhibitor of xanthine oxidase, but it is also a substrate (75), the oxidation resulting in the corresponding xanthine analog, oxypurinol (called alloxantine, oxoallopurinal, or oxipurinol in early papers) which is also a xanthine oxidase inhibitor (Fig. 4).
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Patients with poor kidney function require lower doses of drug because of the pharmacological properties of oxypurinol and its long half-life (88).
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Because allopurinol is completely absorbed orally, whereas oxypruinol in not, allopurinol remains the ideal pro-drug for oxypurinol.
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In addition, there were no pharmacokinetic drug-drug interactions between BCX4208 and either allopurinol or its active metabolite, oxypurinol.
unknown title 2011
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No clinically relevant drug interactions were observed between RDEA594 and allopurinol in this study; however, consistent with prior experience, plasma levels of oxypurinol, an active metabolite of allopurinol, were decreased approximately 25-35 percent.
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