oxysterol

Last month, scientists took an important step toward this goal when researchers at Washington University School of Medicine in St. Louis and the National Institutes of Health announced that they found a unique oxysterol profile for a rare inheritable disease called Niemann-Pick Type C, a fatal cholesterol metabolism disorder.

Decoding a New Disease Culprit Amy Dockser Marcus 2010

When a third oxysterol was also measured, they were accurate predictors of the severity of the disease.

Decoding a New Disease Culprit Amy Dockser Marcus 2010

Scientists say that someone ' s level of oxysterols is independent of cholesterol levels; someone with high cholesterol can have normal oxysterol levels and someone with normal cholesterol may have abnormal oxysterol levels.

Decoding a New Disease Culprit Amy Dockser Marcus 2010

More research still needs to be done, but ultimately oxysterol levels might be used to identify carriers, who might want to take preventive measures against heart disease.

Decoding a New Disease Culprit Amy Dockser Marcus 2010

Scientists say they hope to develop an " oxysterol profile " that would be associated with a certain disease and allow doctors to identify people who might be at higher risk for a condition.

Decoding a New Disease Culprit Amy Dockser Marcus 2010

The deleterious effects of this oxysterol ranged from Abeta accumulation to oxidative cell damage.

BioMed Central - Latest articles Bhanu Dasari 2010

Consistent with the finding that sPLA2-IIA can partially protect oligodendrocytes against oxysterol-triggered apoptosis, we demonstrate here that the inhibition of sPLA2-IIA by Dex accelerates the apoptotic phenomenon, leading to a shift towards necrosis.

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As glucocorticoids are well-known for their anti-inflammatory effects, our aim was to understand their direct effects on oxysterol-induced responses in oligodendrocytes (sPLA2-IIA stimulation and apoptosis).

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Our results provide a new understanding of the cross-talk between oxysterol and glucocorticoid signaling pathways and their respective roles in apoptosis and oligodendrocyte functions.

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This inhibition is mediated by the glucocorticoid receptor (GR), which decreases the expression of the oxysterol receptor Pregnane X Receptor (PXR) and interferes with oxysterol signaling by recruiting a common limiting coactivator PGC1α.

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