palmitoylation love

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The reaction of a membrane protein with a fatty acid (especially palmitic acid) via the sulfur atom of a cysteine amino acid

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

From palmitoyl + -ation.

Examples

  • Figure 4: Downregulation of APT1 increases the steady-state palmitoylation level of Ras.

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  • Here, we discuss the regulatory mechanisms for dynamic protein palmitoylation and the emerging roles of protein palmitoylation in various aspects of pathophysiology, including neuronal development and synaptic plasticity.

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  • Protein palmitoylation, a classical and common lipid modification, regulates diverse aspects of neuronal protein trafficking and function.

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  • The reversible nature of palmitoylation provides a potential general mechanism for protein shuttling between intracellular compartments.

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  • (Asp-His-His-Cys) protein family - and the development of new proteomic and imaging methods have accelerated palmitoylation analysis.

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  • "If we could shift the balance of the palmitoylation, then perhaps we could affect and enhance learning and memory."

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  • Results showed that the NMDA receptor undergoes "dual palmitoylation," in two different regions, each of which plays a distinct role in controlling the fate of the receptor in neurons.

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  • The researchers suspect that if palmitoylation fails, the result would be learning and memory impairment because if NMDA receptors don't make their way to the synapses - the specialized contact points between cells across which chemical messages flow - then communication between neurons is compromised.

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  • The most frequently acylated residues within proteins are lysines (as in histone N-acetylation) and cysteines (as in protein S-palmitoylation); serines seem to be seldom acylated.

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  • Kawasaki K, Ernst RK, Miller SI (2004) Deacylation and palmitoylation of lipid A by Salmonellae outer membrane enzymes modulate host signaling through Toll-like receptor 4.

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