Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A hydroxamic acid drug and acts as a non-selective histone deacetylase inhibitor

Etymologies

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Examples

  • Dr. Gupta noted that panobinostat is effective at extremely low concentrations that are consistent with optimal pharmacological doses.

    Health News from Medical News Today

  • In a study being presented at the annual meeting of the American Association for Cancer Research, Mayo Clinic Cancer Center investigators found that rapamycin and panobinostat (also known as LBH589) act synergistically when used in combination, destroying up to 65 percent of cultured pancreatic tumor cells.

    Health News from Medical News Today

  • "Overall, these results indicate that rapamycin and panobinostat disrupts essential survival and proliferating pathways in pancreatic cancer cells, and this is a good start toward a novel treatment of this cancer," Dr. Gupta says.

    Health News from Medical News Today

  • Targeting heat shock response protein with panobinostat, combined with an autophagy inhibitor, is an effective treatment strategy against growing stress cells in breast cancer.

    THE MEDICAL NEWS

  • Targeting autophagy induced by pan-HDAC inhibitor panobinostat and promoted by acetylated hsp70: A novel therapy for breast cancer

    THE MEDICAL NEWS

  • Treatment with panobinostat induced acetylation of amino acid lysine in the hsp70 protein.

    THE MEDICAL NEWS

  • The first presentation will review non-clinical data with the SuperGen compound SGI-1776 in therapeutic combination model systems with panobinostat, and the second presentation will discuss the early data generated from the new Axl kinase program.

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  • Furthermore, in diseases that involve plasma cells such as multiple myeloma, panobinostat inhibits HDAC6 (a key enzyme in the elimination of pathologically hypersecreted monoclonal immunoglobulins) leading to cell death.

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  • By interfering in the nucleus with gene expression and transcription, panobinostat decreases tumor cell division, causes tumor cell death and inhibits the formation of new blood vessels that feed tumors.

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