Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A
hydroxamic acid drug and acts as a non-selectivehistone deacetylase inhibitor
Etymologies
Sorry, no etymologies found.
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Examples
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Furthermore, in diseases that involve plasma cells such as multiple myeloma, panobinostat inhibits HDAC6 (a key enzyme in the elimination of pathologically hypersecreted monoclonal immunoglobulins) leading to cell death.
unknown title 2009
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Furthermore, in diseases that involve plasma cells such as multiple myeloma, panobinostat inhibits HDAC6 (a key enzyme in the elimination of pathologically hypersecreted monoclonal immunoglobulins) leading to cell death.
unknown title 2009
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Targeting autophagy induced by pan-HDAC inhibitor panobinostat and promoted by acetylated hsp70: A novel therapy for breast cancer
THE MEDICAL NEWS 2009
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The first presentation will review non-clinical data with the SuperGen compound SGI-1776 in therapeutic combination model systems with panobinostat, and the second presentation will discuss the early data generated from the new Axl kinase program.
unknown title 2009
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Treatment with panobinostat induced acetylation of amino acid lysine in the hsp70 protein.
THE MEDICAL NEWS 2009
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Targeting heat shock response protein with panobinostat, combined with an autophagy inhibitor, is an effective treatment strategy against growing stress cells in breast cancer.
THE MEDICAL NEWS 2009
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In a study being presented at the annual meeting of the American Association for Cancer Research, Mayo Clinic Cancer Center investigators found that rapamycin and panobinostat (also known as LBH589) act synergistically when used in combination, destroying up to 65 percent of cultured pancreatic tumor cells.
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Dr. Gupta noted that panobinostat is effective at extremely low concentrations that are consistent with optimal pharmacological doses.
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"Overall, these results indicate that rapamycin and panobinostat disrupts essential survival and proliferating pathways in pancreatic cancer cells, and this is a good start toward a novel treatment of this cancer," Dr. Gupta says.
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The first presentation will review non-clinical data with the SuperGen compound SGI-1776 in therapeutic combination model systems with panobinostat, and the second presentation will discuss the early data generated from the new Axl kinase program.
unknown title 2009
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