Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A gene that is related to another gene in the same organism by descent from a single ancestral gene that was duplicated and that may have a different DNA sequence and biological function.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun genetics either of a pair of
genes that derive from the sameancestral gene
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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In mammals, the cecum expresses Hox paralogs groups 9-11, but the large intestine expresses Hox paralog groups 9-12.
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Consistently, zebrafish embryos carrying mutations in bulldog that codes for the Sec24D paralog, suffer skeletal dysmorphologies caused by the failure to secret ECM material
PLoS ONE Alerts: New Articles Michaela Norum et al. 2010
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Annual Review of Microbiology 44: 429-449. van Schaijk BCL, van Dijk MR, van de Vegte-Bolmer M, van Gemert GJ, van Dooren MW, et al. (2006) Pfs47, paralog of the male fertility factor Pfs48/45, is a female specitic surface protein in Plasmodium falciparum.
PLoS ONE Alerts: New Articles Arthur M. Talman et al. 2010
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While zebrafish embryos deficient for all three SUMO paralogs, as Ubc9-deficient ones, displayed severe defects, loss of individual SUMO paralog was compatible with a normal development.
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Annual Review of Microbiology 44: 429-449. van Schaijk BCL, van Dijk MR, van de Vegte-Bolmer M, van Gemert GJ, van Dooren MW, et al. (2006) Pfs47, paralog of the male fertility factor Pfs48/45, is a female specitic surface protein in Plasmodium falciparum.
PLoS ONE Alerts: New Articles Arthur M. Talman et al. 2010
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Reduction in the activity of Nek7 or its close paralog, Nek6, has previously been shown to arrest cells in mitosis, mainly at metaphase.
Naturejobs - All Jobs H Salem 2010
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Thus, biallelic germline mutations in a RAD51 paralog are associated with an FA-like syndrome.
Naturejobs - All Jobs Fiona Vaz 2010
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This protein lacks the complete domain set common to Sec23/Sec24 proteins, including the Sec23/24 (vWFA-like) domain, and only consists of a region which is specific to this Sec24 paralog and which is predicted to be unstructured.
PLoS ONE Alerts: New Articles Michaela Norum et al. 2010
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RAD51 paralog and support the 'common disease, rare allele' hypothesis.
Naturejobs - All Jobs Alfons Meindl 2010
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The paralog prediction uses automatically generated maximum-likelihood phylogenetic trees.
PLoS ONE Alerts: New Articles Benjamin Schuster-B�ckler et al. 2010
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