Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. either of a pair of genes that derives from the same ancestral gene.
  • n. a pair of genes that derives from the same ancestral gene and now reside at different locations within the same genome.

Etymologies

Sorry, no etymologies found.

Examples

  • This process requires the functions of various molecules including the transmembrane myoblast attractants Dumbfounded (Duf) and its paralogue Roughest (Rst), a scaffold protein Rolling pebbles (Rols) and a guanine nucleotide exchange factor Loner.

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  • Strunkelnberg M, Bonengel B, Moda LM, Hertenstein A, de Couet HG, et al. (2001) rst and its paralogue kirre act redundantly during embryonic muscle development in Drosophila.

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  • The FCs express the myoblast attractants, Dumbfounded (Duf)/Kin of irregular-chiasm-C (Kirre) and its paralogue Roughest (Rst)/Irregular chiasm-C (IrreC)

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  • There are examples of other paralogue genes in zebrafish showing differences in expression patterns

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  • Researchers have therefore increased the severity of the murine dystrophin-deficiency phenotype by creating double mutants: either mice lacking both dystrophin and its paralogue, utrophin, or both dystrophin and MyoD (a transcription factor important in muscle development and regeneration) [18], [26].

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  • Molecular evolutionary analyses indicated that: rln3a, rln3b and rln are under strong evolutionary constraint, that insl3 has been subject to moderate rates of sequence evolution with two amino acids in insl3/INSL3 showing evidence of positively selection, and that insl5b exhibits a higher rate of sequence evolution than its paralogue insl5a suggesting that it may have been neo-functionalized after the teleost whole genome duplication.

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  • The homB gene is a Helicobacter pylori disease marker candidate, strongly associated with peptic ulcer disease, while homA, its paralogue gene with 90% sequence identity, is correlated with non ulcer dyspepsia.

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  • Six homologues of cold shock proteins (CspA, − B, C, D, G, H, I), among which two copies of cspC were included, were discerned to represent one of the largest paralogue gene family in EIB202.

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  • Keren-Paz A, Bercovich Z, Kahana C (2008) ODCp, a brain - and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1.

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