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- n. An analog of calcitriol (the active form of vitamin D) that is used for the prevention and treatment of secondary hyperparathyroidism
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ADVANCE studied 360 patients with SHPT and detectable CAC who were randomised to open label treatment with cinacalcet (30-180 mg/day) plus low-dose vitamin D (less than or equal to 2 ug IV paricalcitol equivalent/dialysis session) or to flexible vitamin D therapy.
Thus, paricalcitol appears to attenuate CsA-induced nephropathy by suppression of inflammatory, pro-fibrotic, and apoptotic factors through inhibition of the nuclear factor-κB, Smad, and mitogen-activated protein kinase signaling pathways.
In addition, paricalcitol decreased the number of TUNEL-positive nuclei and reduced the expression of pro-apoptotic markers in CsA-treated HK-2 cells.
Using an in vitro model, we treated HK-2 cells with CsA and found that paricalcitol attenuated the CsA-induced increases in phosphorylated extracellular signal-regulated and c-Jun
Abbott Laboratories 'Zemplar (paricalcitol); and Amgen Inc's Sensipar (cinacalcet). chronic kidney disease, which is associated with low vitamin D levels.
Either way, he said there are drugs that can lower them, including Fontus Pharmaceuticals Inc's Rocaltrol, also called calcitriol; Genzyme Corp's Hectorol (doxercalciferol); Abbott Laboratories 'Zemplar (paricalcitol); and Amgen Inc's Sensipar (cinacalcet).
Genzyme Corp's Hectorol (doxercalciferol); Abbott Laboratories 'Zemplar (paricalcitol); and Amgen Inc's Sensipar (cinacalcet).