from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Alternative form of PEGylation.
Sorry, no etymologies found.
One notable strategy is through pegylation, which involves the attachment of polyethylene glycol polymers to the therapeutic protein to mask the molecule from the host immune system and thereby reduce immunogenicity and antigenicity.
One concern has been that pegylation could interfere with the biological activity and with the replacement factor's binding with von Willebrand factor, which is the primary determinant of factor VIII's half life in plasma.
Based on more than a decade of research, Sangart has refined the pegylation of human hemoglobin to create a molecule, MP4, with the ability to carry oxygen through the circulatory system to prevent and treat ischemia.
Nektar has transformed from a company essentially selling a commodity, pegylation ingredients, to a company that has created and monetized an extremely deep pipeline.