Definitions

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  • n. A particular drug used in chemotherapy.

Etymologies

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Examples

  • Other approved therapies, such as pemetrexed (Alimta ™) are indicated for non-squamous NSCLC only. 3

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  • Other approved therapies, such as pemetrexed (Alimta ™) are indicated for non-squamous NSCLC only. 2

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  • ONX 0801 is distinct from currently marketed thymidylate synthase inhibitors such as pemetrexed, 5 fluorouracil, and capecitabine because of its selective tumor cell uptake by the alpha-folate receptor but is similar in its intracellular mechanism of action.

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  • Some side effects such as nausea and vomiting, stomatitis, and diarrhoea were more common in the combination pemetrexed group but only affected a minority of patients and overall the combination of pemetrexed and cisplatin was well tolerated when patients received vitamin supplementation; both quality of life and lung function tests improved in the combination pemetrexed group.

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  • Vitamin supplementation was given to most patients in the trial and pemetrexed related side effects were significantly less in patients receiving pemetrexed when they also received daily oral folate 500mcg and intramuscular vitamin B12 1000mcg every 9 weeks compared with patients receiving pemetrexed without vitamin supplementation.

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  • In February 2004, the United States Food and Drug Administration approved pemetrexed for treatment of malignant pleural mesothelioma.

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  • For patients unable to tolerate pemetrexed, cisplatin in combination with gemcitabine or vinorelbine is an alternative, although a survival benefit has not been shown for these drugs.

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  • Cisplatin in combination with raltitrexed has shown an improvement in survival similar to that reported for pemetrexed in combination with cisplatin, but raltitrexed is no longer commercially available for this indication.

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  • This trial was the first to report a survival advantage from chemotherapy in malignant pleural mesothelioma showing a statistically significant improvement in median survival from 10 months in the patients treated with cisplatin alone to 13.3 months in the combination pemetrexed group in patients who received supplementation with folate and vitamin B12.

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  • The objective response rate increased from 20% in the cisplatin group to 46% in the combination pemetrexed group.

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