Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun An
antiepileptic drug .
Etymologies
Sorry, no etymologies found.
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Examples
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The two latest perampanel trials both involved patients experiencing at least four partial seizures per month despite therapy with up to three regular epilepsy medications.
MedPageToday.com - medical news plus CME for physicians 2009
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About 83\% of patients were able to tolerate 4 mg / day of perampanel, nearly identical to the
MedPageToday.com - medical news plus CME for physicians 2009
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The findings "provide preliminary support" for perampanel as an effective add-on for refractory partial seizures, Dr. Krauss concluded.
MedPageToday.com - medical news plus CME for physicians 2009
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The second trial involved 48 patients who were assigned in a 3: 1 ratio to perampanel or placebo.
MedPageToday.com - medical news plus CME for physicians 2009
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Explain that perampanel is not FDA-approved for any purpose and is available only in a clinical trial setting.
MedPageToday.com - medical news plus CME for physicians 2009
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Among 38 patients assigned to perampanel in the second study, 18 were able to tolerate 8 mg; 14 could tolerate 10 mg, and 12 tolerated 12 mg, Dr. Krauss reported.
MedPageToday.com - medical news plus CME for physicians 2009
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Researchers found the 40\% reduction in median seizure frequency in this study among all perampanel patients at the highest dose given.
MedPageToday.com - medical news plus CME for physicians 2009
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One of the studies randomized 153 patients to placebo or perampanel at doses of 4 mg daily or 2 mg twice daily in equal-size groups, with treatment lasting 12 weeks.
MedPageToday.com - medical news plus CME for physicians 2009
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Median seizure frequency was reduced by 40\% with perampanel in one of the two studies, compared with a 2\% increase with placebo, Dr. Krauss told attendees at the American Academy of Neurology's annual meeting here.
MedPageToday.com - medical news plus CME for physicians 2009
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From 30\% to 40\% of patients treated with perampanel in two placebo-controlled phase IIa trials had at least 50\% reductions in seizure frequency at maximally tolerated doses, Gregory Krauss, M.D., of Johns Hopkins, reported.
MedPageToday.com - medical news plus CME for physicians 2009
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