from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. Describing a connective route from the entorhinal cortex to the hippocampus

from The Century Dictionary and Cyclopedia

  • Perforating, as the tendon of a flexor muscle.


Sorry, no etymologies found.


  • The new study suggests that deep brain stimulation targeted to the entorhinal cortex or perforant path could ameliorate these memory deficits, but this, too, will need to be tested.

    Deep brain stimulation enhances spatial memory

  • Previous studies have shown that direct stimulation of the human hippocampus has detrimental effects on memory, but these new results identify the entorhinal cortex, and possibly the perforant path, as potential targets for memory enhancement.

    Deep brain stimulation enhances spatial memory

  • Seven such patients had the DBS electrodes implanted for between 7- 10 days, in the hippocampus or the adjacent entorhinal cortex, which connects to the hippocampus via the perforant path, or both.

    Deep brain stimulation enhances spatial memory

  • Nashmi R, Xiao C, Deshpande P, McKinney S, Grady SR, et al. (2007) Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path.

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  • Here we found that perforant path stimulation in rat hippocampal slices evoked long-lasting barrages of synaptic inputs in subpopulations of dentate gyrus mossy cells and hilar interneurons.

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  • After 2 h of equilibration the medial perforant path was stimulated and the evoked potentials in the dentate gyrus were recorded in the molecular layer above the upper blade by using a glass capillary microelectrode filled with artificial cerebrospinal fluid

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  • Consequently, unless the GABAergic inhibition of granule cells is blocked, stimulating the medial perforant path with high-frequency bursts elicits a weak LTP in the DG that is based on the newly generated neurons

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  • This study focuses on the layer III of the medial entorhinal cortex, which provides input to the hippocampal CA1 region and subiculum via the perforant path.

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  • Vago DR, Bevan A, Kesner RP (2007) The role of the direct perforant path input to the CA1 subregion of the dorsal hippocampus in memory retention and retrieval.

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  • Also LIII mEC neurons project via the perforant path to the CA1 and Subiculum region.

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