from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. Situated near, or on each side of, the centromere of a chromosome
Sorry, no etymologies found.
Genomic segments of various lengths from different regions of the genome were duplicated to an ancestral pericentromeric region followed by the dispersal of a mosaic genomic segment to multiple pericentromeric regions.
This aberration was corroborated by interphase fluorescence in situ hybridization, using a chromosome 18 pericentromeric probe, in the basaloid epithelial component of 7 of 11 pilomatricomas, including the index case.
CNVs are found more often in pericentromeric and subtelomeric regions and they overlap significantly with regions of segmental duplications.
Lockett S, Muegge K (2003) Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin.
The chromocenter acts as a hub for the deposition of heterochromatic markers, controlling centromeric and pericentromeric DNA replication timing and chromosome segregation.