from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An experimental alkylphospholipid anticancer drug.


Sorry, no etymologies found.


  • Bentsur added that KERX would consider licensing its colon cancer drug, known as perifosine, or perhaps even sell the drug on its own.

  • They have their product, which is called perifosine, in Phase III development for multiple myeloma, where they have already seen robust Phase II data in relapsed refractory multiple myeloma, MM, patients.

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  • In the current study, researchers looked at a drug called perifosine, which inhibits the Akt pathway.


  • AEterna Zentaris, said the Food and Drug Administration plans to expedite its review of their colorectal cancer treatment perifosine.

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  • Early development of the Erk inhibitor AEZS-131 is an integral part based on our knowledge with perifosine of Aeterna Zentaris' kinase research program comprising the investigation of different compounds for single Erk inhibition, single PI3K inhibition and dual Erk/PI3K kinase inhibition.

  • Juergen Engel, Ph.D., Aeterna Zentaris' President and Chief Executive Officer, commented: As part of our targeting strategy in cancer with perifosine, AEZS-108, AEZS-112 and AEZS-120, we are proud to have identified the first in class Erk 1/2 inhibitor with in vivo anticancer activity.

  • Keryx is developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway, and also affects other signal transduction pathways, including the JNK pathway, believed to be associated with cell death, growth, differentiation and survival.

  • Hopefully, Aeterna and Keryx haven't jinxed the perifosine by naming the phase 3 trial "X-PECT" Xeloda + Perifosine Evaluation in Colorectal cancer Treatment.

  • So what: Keryx licensed the rights to colorectal cancer treatment perifosine from Aeterna Zentaris Nasdaq: AEZS and is progressing nicely on the path to getting the drug approved and on the market.

  • AEZ-T jumped above the $2 mark early Wednesday after saying the independent Data Safety Monitoring Board DSMB for the pivotal Phase 3 X-PECT study of perifosine in patients with refractory advanced colorectal cancer has completed a pre-specified interim analysis for safety and futility.

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