Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective pathology That surrounds a
hematoma
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Mechanical forces that occur during hematoma formation and the chemical toxicity induced by the perihematomal inflammatory reaction may cause necrosis in the adjacent brain tissue [53].
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In experimental models of ICH, an initial loss of astrocytes followed by strong astroglial activation in the core and in the perihematomal area has been observed [71,72].
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Cellular mediators Leukocytes infiltrate the perihematomal area in the first 24 hours.
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On the other hand, opponents argue that lowering blood pressure may worsen secondary brain damage by causing cerebral ischemia, especially in the perihematomal area.
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However, the concept of perihematomal ischemia has been challenged.
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[54] Gebel JM, Jauch EC, Brott TG, et al. Natural history of perihematomal edema in patients with hyperacute spontaneous intracerebral hemorrhage.
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TNFa and IL-6 have been found to increase in the peripheral blood of patients with spontaneous ICH admitted within 24 hours of onset, and this rise is associated with the magnitude of subsequent perihematomal edema [51].
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Inflammatory mediators of secondary brain damage A robust inflammatory reaction occurs in the perihematomal area, contributing to secondary brain damage.
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Positron emission tomography studies suggest that the perihematomal area has low cerebral metabolic rate for oxygen and reduced CBF, suggesting metabolic suppression rather than ischemia.
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Active microglia can express heme oxygenase, release cytokines (TNFa and interleukins), generate ROS, and contribute significantly to leukocyte recruitment and astrocyte activation in the perihematomal area [51,69,70].
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