from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A protein normally expressed during cardiac development but also re-expressed following injury to adult tissue


Sorry, no etymologies found.


  • Kühn developed a sponge-like patch, soaked in a compound called periostin that is abundant in the developing fetal heart (and in injured skeletal muscle) but scarce in adult hearts.


  • Hajjar's lab at Mt. Sinai is now testing one of the peptides, periostin, in pigs induced to have heart attacks.

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  • A similar test with peptide, periostin was also conducted on pigs induced to have heart attacks. - latest science and technology news stories

  • The new work adds a second compound to the heart-regeneration toolbox, and reveals how both periostin and NRG-1 work at the cellular and molecular level, an essential step in predicting possible side effects.


  • Similar results were seen in larger animals, and periostin is now in preclinical development at Children's Hospital Boston for future application in human patients with heart failure.


  • The researchers recently completed a study of periostin in pigs, but the findings have not been published.

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  • Neuregulin1 is not the first substance identified by the authors that promotes heart muscle cell growth. protein periostin, found in the developing fetal heart and injured skeletal muscles, also induced cardiomyocyte production and improved heart function in rats.

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  • ICU they might be taken to the cath lab for a periostin patch, "Kuhn says.

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