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- n. A large multidomain proteoglycan.
Sorry, no etymologies found.
It is believed that proteoglycans such as perlecan, which are rich in the sulphated glycosaminoglycan heparan sulphate, play an important role in the retention of lipoproteins to endothelial extracellular matrix.
Indeed, ApoE knockout mice which were also deficient in perlecan-associated heparan sulphate were found to be protected from development of atherosclerosis, compared to heparan sulphate sufficient controls
Tran-Lundmark K, Tran PK, Paulsson-Berne G, Friden V, Soininen R, et al. (2008) Heparan sulfate in perlecan promotes mouse atherosclerosis: roles in lipid permeability, lipid retention, and smooth muscle cell proliferation.
Golgi-mediated glycosylation events were altered in fibroblasts and chondrocytes lacking GMAP-210, and these chondrocytes had intracellular accumulation of perlecan, an extracellular matrix protein, but not of type II collagen or aggrecan, two other extracellular matrix proteins.