from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A large multidomain proteoglycan.


Sorry, no etymologies found.


  • It is believed that proteoglycans such as perlecan, which are rich in the sulphated glycosaminoglycan heparan sulphate, play an important role in the retention of lipoproteins to endothelial extracellular matrix.

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  • Indeed, ApoE knockout mice which were also deficient in perlecan-associated heparan sulphate were found to be protected from development of atherosclerosis, compared to heparan sulphate sufficient controls

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  • Tran-Lundmark K, Tran PK, Paulsson-Berne G, Friden V, Soininen R, et al. (2008) Heparan sulfate in perlecan promotes mouse atherosclerosis: roles in lipid permeability, lipid retention, and smooth muscle cell proliferation.

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  • Golgi-mediated glycosylation events were altered in fibroblasts and chondrocytes lacking GMAP-210, and these chondrocytes had intracellular accumulation of perlecan, an extracellular matrix protein, but not of type II collagen or aggrecan, two other extracellular matrix proteins.

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