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- n. Plural form of phagolysosome.
Sorry, no etymologies found.
Upon latex-bead phagocytosis, native Irgm1 rapidly re-localises in IFNγ-induced fibroblasts and macrophages to F-actin-rich plasma membrane ruffles associated with phagocytic cups, and remains associated with the phagosomes as they mature into phagolysosomes and become LAMP1 positive
Albeit mycobacteria reside within phagolysosomes of the infected macrophages, envelope glycoconjugates like Lipoarabinomannan (LAM), phosphatidyl - myo-inositol mannosides (PIM), Trehalose 6,6′-dimycolate (TDM; cord factor) etc., are released and traffic out of the mycobacterial phagosome into endocytic compartments as well as can gain access to the extracellular environment in the form of exocytosed vesicles
Using this approach we clearly demonstrated for the fist time, that levels of acidification in phagolysosomes are increased in peripheral cells of CHM patients leading to the significantly reduced rates of proteolytic degradation.
Further, inhibition of lysosomal enzymes in the RPE leads to attenuation of exocytosis and release of incompletely degraded phagolysosomes into the basal and intercellular spaces between adjacent cells in vivo, may be especially susceptible to toxicity and degeneration caused by defects in lysosome-mediated degradation and impaired secretion.
Confocal imaging of the phagocytosing CHM and control monocytes demonstrated the presence of fluorescent BioParticles inside of the phagolysosomes (