Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. Of or pertaining to a phagosome.

Etymologies

Sorry, no etymologies found.

Examples

  • Using a high-throughput visual assay, the researchers screened for mutant mycobacteria that had lost the ability to arrest phagosomal maturation.

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  • Irgm1 accumulated around the latex beads phagosomes (seen as refringent spheres) while the loss of the nucleotide-binding site completely abolished the phagosomal accumulation.

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  • Since accumulation of full-length Irgm1 on phagosomes depended on the integrity of the nucleotide-binding motif, it seems that another GTP-dependent conformationally active region of full-length Irgm1 must contribute to the phagosomal accumulation of the protein.

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  • Wild type Irgm1 strongly associated with latex bead-phagosomes while accumulation of Irgm1 (S90N) on the phagosomal membrane was much reduced

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  • Functions encoded by the operon appear to be essential for the phagosomal escape and intracellular growth, since disruptions or deletions of FPI encoded genes of the low virulent strains

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  • The bacterium initially resides in a phagosome before it escapes into the cytoplasm via degradation of the phagosomal membrane.

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  • Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, et al. (2003) Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment.

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  • In search of a possible explanation for the attenuation of Kim53Δ nlpD, we evaluated the involvement of Y. pestis NlpD in resistance to prolonged growth in rich (HIB) and minimal (M9) broth, and in acidic and oxidative conditions that simulate the intra-phagosomal milieu.

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  • AERAS-401, a recombinant BCG, encodes a functionally attenuated mutated perfringolysin O allele, pfoAG137Q which leads to perforation of the phagosomal membrane of the host cell.

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  • Choi HP, Matsuzawa T, Pypaert M, MacMicking JD (2009) Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns (3,4) P (2) and PtdIns (3,4,5) P (3) promotes immunity to mycobacteria.

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