from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A tricyclic aromatic heterocycle formally derived from phenanthrene by substituting a nitrogen atom for a CH group in the central ring
from the GNU version of the Collaborative International Dictionary of English
- n. A nitrogenous hydrocarbon base, C13H9N, analogous to phenanthrene and quinoline.
from The Century Dictionary and Cyclopedia
- n. A crystalline basic compound, , formed by passing the vapor of benzylidene aniline through a red-hot tube. The aqueous solution has a slight blue fluorescence. It melts at 104° C.
Sorry, no etymologies found.
Led by Professor Cohen-Armon of Tel-Aviv University, the researchers found that potent phenanthridine derived polyADP-ribose polymerase (PARP) inhibitors efficiently eradicate MCF-7 and MDA231 breast cancer cells without impairing normal proliferating cells, such as human epithelial cells (MCF-10A), nor normal non-proliferating cells, such as neurons and cardiomyocytes.
Prof. Malka Cohen-Armon of TAU's Sackler School of Medicine found that the stroke drug -- a member of a family of phenanthridine derivatives developed by an American drug company -- worked to kill cancer in mice which had been implanted with human breast cancer cells.
Prof. Malka Cohen-Armon found that the stroke drug - a member of a family of phenanthridine derivatives developed by an American drug company - worked to kill cancer in mice which had been implanted with human breast cancer cells.
The phenanthridine PJ-34 caused a permanent G2/M cell-cycle arrest and cell death within 48-72 hours in breast cancer MCF-7 and MDA231 cells.
A selective eradication of human non-hereditary breast cancer cells by phenanthridine derived polyADP-ribose polymerase inhibitors PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro
< 1-5 > (< 1-5 >, the enzyme is specifically present in different plant species that produce benzo [c] phenanthridine alkaloids in culture )  503