Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. (genetics) The complete set of phosphatases found in a biological sample; especially that found in a person's body under normal conditions, and when suffering from a disease

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

phosphatase +‎ -ome

Examples

  • Ugochukwu E, Lee WH, King ON, Filippakopoulos P, et al. (2009) Large-scale structural analysis of the classical human protein tyrosine phosphatome.

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  • Large scale super-family sequencing projects, i.e. the kinome and phosphatome projects, followed and showed that, although missense mutations are found in some members of these two superfamilies, they are not a common ground for somatic cancer mutations.

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  • The considerable phylogenetic distance between Apicomplexa and other Eukaryotes is reflected by profound divergences between the phosphatome of malaria parasites and those of representative organisms from all major eukaryotic phyla, which might be exploited in the context of efforts for the discovery of novel targets for antimalarial chemotherapy.

    BioMed Central - Latest articles

  • (i) P. falciparum possessed the smallest phosphatome of any of the organisms investigated in this study; (ii) no malarial PP clustered with the tyrosine-specific subfamily of the PTP group (iii) a cluster of 7 closely related members of the PPM / PP2C family is present, and (iv) some P. falciparum protein phosphatases are present in clades lacking any human homologue.

    BioMed Central - Latest articles

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