phosphoinositide love



from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The inositol ester of phosphoric acid that is a component of phosphatidylinositols


Sorry, no etymologies found.


  • Both compounds target an enzyme called phosphoinositide-3 kinase, or PI3K.

    San Jose Business News - Local San Jose News | The Silicon Valley / San Jose Business Journal

  • PTEN plays a vital role in the suppression of humans cancers by inhibiting a genetic pathway called phosphoinositide-3 kinase (PI3K).

    R&D Mag - News

  • * The phosphoinositide 3-phosphatase PTEN is known to play a role in the regulation of insulin signaling.

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  • Progenics' pipeline candidates include PSMA ADC, a human monoclonal antibody-drug conjugate in phase 1 testing for treatment of prostate cancer, and preclinical stage novel multiplex phosphoinositide 3-kinase PI3K inhibitors for the treatment of cancer.

  • As Akt pathway has been associated with survival and proliferation, Akt inhibition in the phosphoinositide 3-kinase PI3K pathway is an attractive approach for treating disorders 1 characterized by uncontrolled growth of cell, e.g. - cancer

  • Keryx is developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway, and also affects other signal transduction pathways, including the JNK pathway, believed to be associated with cell death, growth, differentiation and survival.

  • Prevents blood clots that cause strokes and heart attacks by inhibiting the enzyme phosphoinositide 3-kinase.

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  • Food and Drug Administration (FDA) granted Fast Track designation for perifosine, a novel, potentially first-in-class, oral anti - cancer agent that inhibits the phosphoinositide


  • Researchers are taking a closer look at the phosphoinositide 3-kinase (PI3-kinase) pathway as studie ...


  • We used this P-loop signature as a "diagnostic motif" to identify related putative phosphatases with phosphoinositide activity in other organisms.

    BioMed Central - Latest articles


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