Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells.

Etymologies

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Examples

  • Used nuclear magnetic resonance imaging to analyze a protein, phospholamban.

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  • Haghighi K, Kolokathis F, Gramolini AO, Waggoner JR, Pater L, et al. (2006) A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.

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  • Sugita Y, Kurzydlowski K, De Leon S, Tada M, et al. (2003) Sarcolipin regulates sarco (endo) plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban.

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  • Stenoien DL, Knyushko TV, Londono MP, Opresko LK, Mayer MU, et al. (2007) Cellular trafficking of phospholamban and formation of functional sarcoplasmic reticulum during myocyte differentiation.

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  • Mutagenesis and deletion of cDNA encoding rabbit phospholamban (PLN) containing a deletion of the arginine residue at position 14 has been described in previous publications

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  • In cardiac muscle, SERCA2a can associate with a 52-amino acid transmembrane phosphoprotein, phospholamban (PLN) [1].

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  • Western blot analysis detected greatly reduced presence of SR markers (calsequestrin, SERCA2a, and phospholamban) in pRHM, suggesting that the mitochondria-associated particles represented a small subfraction of the SR.

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  • Ca2+ sequestration, since the ratio of phosphorylated phospholamban to total phospholamban was sharply reduced in all three mutant hearts.

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