Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. Of or pertaining to phosphonic acid or its derivatives

from the GNU version of the Collaborative International Dictionary of English

  • adj. Pertaining to, or designating, certain derivatives of phosphorous acid containing a hydrocarbon radical, and analogous to the sulphonic acid.

from The Century Dictionary and Cyclopedia

  • Derived from phosphorus.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

From phosphorus by analogy with sulfonic

Examples

  • The injection of constant low levels of phosphonic acid may solve iron clogging problems.

    Food and Farm News

  • Here, we developed a new strategy to overcome BPs hydrophilicity by masking the phosphonic acid through organic protecting groups and introducing hydrophobic functions in the side chain.

    PLoS ONE Alerts: New Articles

  • Here, we showed that the symmetrical esterification of the phosphonic groups may improved BPs soft tissue bioavaibility limiting osseous or calcified tissue uptake.

    PLoS ONE Alerts: New Articles

  • However, we hypothesised that release of BP7033Br ALK with free phosphonic group could be more important in in vivo system because of the presence of phosphodiesterases in serum.

    PLoS ONE Alerts: New Articles

  • Previously, our laboratory developed a new strategy to overcome BP hydrophilicity by masking the phosphonic acid with organic protecting groups and introducing hydrophobic functions in the side chain

    PLoS ONE Alerts: New Articles

  • Also, zoledronate was a compound rapidly eliminated from plasma, resulting in renal excretion, rapid bone or calcified tissues uptake and accumulation partly due to its phosphonic functions.

    PLoS ONE Alerts: New Articles

  • Since MMPs are zinc-dependent endopeptidases, we speculated that the reduction of BP7033Br ALK effect could be due to a reduction of available phosphonic acid groups able to chelate zinc and consequently inhibit MMPs.

    PLoS ONE Alerts: New Articles

  • These data were in agreement with our previous results on epidermoid A431 cell proliferation that showed a beneficial effect of esterification of the phosphonic groups

    PLoS ONE Alerts: New Articles

  • (0. 3-7\% in humans) due to chelation of metal ions by phosphonic acid group inside the digestive lumen, poor membrane permeability due to poor BP lipophilicity as well as strong uptake by bone tissue

    PLoS ONE Alerts: New Articles

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