Definitions
from The Century Dictionary.
- Derived from phosphorus.
from the GNU version of the Collaborative International Dictionary of English.
- adjective (Chem.) Pertaining to, or designating, certain derivatives of phosphorous acid containing a hydrocarbon radical, and analogous to the sulphonic acid.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective Of or pertaining to
phosphonic acid or its derivatives
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
Support
Help support Wordnik (and make this page ad-free) by adopting the word phosphonic.
Examples
-
The injection of constant low levels of phosphonic acid may solve iron clogging problems.
Food and Farm News 2009
-
Here, we developed a new strategy to overcome BPs hydrophilicity by masking the phosphonic acid through organic protecting groups and introducing hydrophobic functions in the side chain.
-
Here, we showed that the symmetrical esterification of the phosphonic groups may improved BPs soft tissue bioavaibility limiting osseous or calcified tissue uptake.
-
However, we hypothesised that release of BP7033Br ALK with free phosphonic group could be more important in in vivo system because of the presence of phosphodiesterases in serum.
-
Previously, our laboratory developed a new strategy to overcome BP hydrophilicity by masking the phosphonic acid with organic protecting groups and introducing hydrophobic functions in the side chain
-
Also, zoledronate was a compound rapidly eliminated from plasma, resulting in renal excretion, rapid bone or calcified tissues uptake and accumulation partly due to its phosphonic functions.
-
Since MMPs are zinc-dependent endopeptidases, we speculated that the reduction of BP7033Br ALK effect could be due to a reduction of available phosphonic acid groups able to chelate zinc and consequently inhibit MMPs.
-
These data were in agreement with our previous results on epidermoid A431 cell proliferation that showed a beneficial effect of esterification of the phosphonic groups
-
(0. 3-7\% in humans) due to chelation of metal ions by phosphonic acid group inside the digestive lumen, poor membrane permeability due to poor BP lipophilicity as well as strong uptake by bone tissue
Comments
Log in or sign up to get involved in the conversation. It's quick and easy.