Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A derivative of
phosphate in which anoxygen atom is replaced withsulfur ; especially such a variant ofnucleic acid
Etymologies
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Examples
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They are hybrid oligonucleotide molecules that RXi believes combine the beneficial properties of both conventional RNAi and antisense technologies. sd-rxRNAs have a single-stranded phosphorothioate region, a short duplex region, and contain a variety of nuclease-stabilizing and lipophilic chemical modifications.
unknown title 2011
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Antisense Pharma is developing trabedersen, a TGF-beta-2 specific phosphorothioate antisense oligonucleotide administered intratumorally using convection-enhanced delivery.
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Antisense Pharma is developing trabedersen, a TGF-beta-2 specific phosphorothioate antisense oligonucleotide administered intratumorally using convection-enhanced delivery.
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The product is a single strand phosphorothioate compound, which has received Orphan Drug designation and is destined for fast-track development.
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Recently the dnd cluster was shown to mediate the incorporation of sulphur into the DNA backbone via a sequence-selective, stereo-specific phosphorothioate modification in
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In 2005, the five-gene dndABCDE cluster responsible for this phenotype was identified in in vivo by the addition of a sulphur-containing molecule through a likely biochemical pathway mediated by enzymes encoded by the More recently the dnd cluster was shown to mediate the incorporation of sulphur into the DNA backbone via a sequence-selective, stereo-specific phosphorothioate modification in
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Misteli T, Baker BF, Bennett CF, Spector DL (2000) Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides.
PLoS ONE Alerts: New Articles Musa M. Mhlanga et al. 2009
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Inactivation of the enzyme by an antisense phosphorothioate oligonucleotide repressed the induction of ceramide generation, caspase-3 activation, and apoptotic cell death by heat stress.
Journal of Biological Chemistry current issue T. Yabu 2008
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