from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A derivative of phosphate in which an oxygen atom is replaced with sulfur; especially such a variant of nucleic acid
Sorry, no etymologies found.
They are hybrid oligonucleotide molecules that RXi believes combine the beneficial properties of both conventional RNAi and antisense technologies. sd-rxRNAs have a single-stranded phosphorothioate region, a short duplex region, and contain a variety of nuclease-stabilizing and lipophilic chemical modifications.
Antisense Pharma is developing trabedersen, a TGF-beta-2 specific phosphorothioate antisense oligonucleotide administered intratumorally using convection-enhanced delivery.
The product is a single strand phosphorothioate compound, which has received Orphan Drug designation and is destined for fast-track development.
Recently the dnd cluster was shown to mediate the incorporation of sulphur into the DNA backbone via a sequence-selective, stereo-specific phosphorothioate modification in
In 2005, the five-gene dndABCDE cluster responsible for this phenotype was identified in in vivo by the addition of a sulphur-containing molecule through a likely biochemical pathway mediated by enzymes encoded by the More recently the dnd cluster was shown to mediate the incorporation of sulphur into the DNA backbone via a sequence-selective, stereo-specific phosphorothioate modification in
Misteli T, Baker BF, Bennett CF, Spector DL (2000) Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides.
Inactivation of the enzyme by an antisense phosphorothioate oligonucleotide repressed the induction of ceramide generation, caspase-3 activation, and apoptotic cell death by heat stress.