phosphorylatable

Indicated serine/threonine-to-alanine non-phosphorylatable raptor mutants were expressed in HEK293T cells treated with taxol as in

PLoS ONE Alerts: New Articles Dana M. Gwinn et al. 2010

Indicated serine/threonine-to-alanine non-phosphorylatable raptor mutants were expressed in HEK293T cells treated with taxol as in

PLoS ONE Alerts: New Articles Dana M. Gwinn et al. 2010

Figure 1. (b, c) Wild-type or non-phosphorylatable raptor alleles were immunoprecipitated from nocadazol treated HEK293T cells and then immunoblotted with indicated site-specific phospho-raptor antibodies.

PLoS ONE Alerts: New Articles Dana M. Gwinn et al. 2010

Cells expressing non-phosphorylatable alleles of raptor continued to progress through mitosis unabated unlike those expressing wild-type raptor, and ultimately displayed increased rates of apoptosis.

PLoS ONE Alerts: New Articles Dana M. Gwinn et al. 2010

Importantly, our data suggests there may be additional cdc2 sites beyond Ser696, Thr706, and Ser711 in raptor and until these sites are fully identified, the phenotype of a fully cdc2 non-phosphorylatable raptor remains unknown.

PLoS ONE Alerts: New Articles Dana M. Gwinn et al. 2010

In addition, D1-K269R is resistant to genotoxic stress-induced degradation, similar to non-phosphorylatable D1-T286A, supporting the critical role for the post-translational regulation of cyclin D1 in response to DNA-damaging agents.

Naturejobs - All Jobs O Barbash 2009

We established that mutations of T426 alter the KaiC phosphorylation profiles in vivo and that residue 426 needs to be phosphorylatable and not simply capable of forming a H-bond to pS431

PLoS ONE Alerts: New Articles Rekha Pattanayek et al. 2009

For example, phosphorylation of Nrf2 by different kinases was reported to play a role in controlling Nrf2 activities although mutagenesis studies have not identified the functional importance of any phosphorylatable residues

PLoS ONE Alerts: New Articles 2009

To define the mechanisms for the autoactivation of primed Cds1 and the regulation of this process, we carried out genetic and biochemical studies to identify phosphorylatable residues required for checkpoint activation.

Journal of Biological Chemistry current issue Y.-j. Xu 2009

In marked contrast, mutation of Ser-164, Thr-205, or Ser-210 to a non-phosphorylatable residue was found to clearly impair checkpoint recovery, as judged by a significant decrease in cumulative mitotic entry at 24 h after irradiation (

PLoS Biology: New Articles Marcel A. T. M. van Vugt et al. 2010