from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A site (on a protein etc) responsible for, or associated with, phosphorylation
Sorry, no etymologies found.
Given that the substrate specificity of a kinase is usually determined by a few key amino-acids surrounding the target phosphosite it is easy to image how kinase-substrate interactions can be easily created and destroyed with few mutations.
The height of the flanking bars indicates conservation within the 11 amino acid region surrounding the phosphosite (grey, 88. 2%).
Interestingly, mapping our phosphorylation sites along with all those from phospho-proteomic databases including PhosphoSitePlus (www. phosphosite.org; ) reveals that phosphorylation sites within raptor cluster to two regions located between the HEAT repeat region and the WD-repeat containing C-terminal of raptor (