Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
phosphorylated derivative oftyrosine that is active in signal transduction and regulation of enzymatic activity
Etymologies
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Examples
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NXXKNRY), known as a phosphotyrosine recognition loop that restricts the substrate specificity to tyrosine-phosphorylated peptide, HD-PTP (
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The anti-optineurin but not rabbit IgG immunoprecipitated proteins were immunoreactive toward anti-phosphotyrosine (left panel) and anti-phosphoserine (middle panel).
PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010
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Using a phosphotyrosine proteomics approach, we screened the
Naturejobs - All Jobs J T Lucas 2010
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Lysate from A431 (human epithelial carcinoma) cell line was used a positive control in anti-phosphotyrosine experiments.
PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010
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The anti-optineurin but not rabbit IgG immunoprecipitated proteins were immunoreactive toward anti-phosphotyrosine (left panel) and anti-phosphoserine (middle panel).
PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010
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Lysate from A431 (human epithelial carcinoma) cell line was used a positive control in anti-phosphotyrosine experiments.
PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010
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Gordon JA (1991) Use of vanadate as protein-phosphotyrosine phosphatase inhibitor.
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In contrast to alanine in that position, Ser1394 in HD-PTP does not form favorable substrate interactions with the bound phosphotyrosine.
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Zambrano N, Minopoli G, Donini V, Duilio A, et al. (1995) The regions of the Fe65 protein homologous to the phosphotyrosine interaction / phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein.
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(His1223) exchange in the HD-PTP phosphotyrosine recognition loop results in the loss of π-π stacking interactions with the substrate.
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