phosphotyrosine love



from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A phosphorylated derivative of tyrosine that is active in signal transduction and regulation of enzymatic activity


Sorry, no etymologies found.


  • NXXKNRY), known as a phosphotyrosine recognition loop that restricts the substrate specificity to tyrosine-phosphorylated peptide, HD-PTP (

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  • Using a phosphotyrosine proteomics approach, we screened the

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  • Lysate from A431 (human epithelial carcinoma) cell line was used a positive control in anti-phosphotyrosine experiments.

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  • The anti-optineurin but not rabbit IgG immunoprecipitated proteins were immunoreactive toward anti-phosphotyrosine (left panel) and anti-phosphoserine (middle panel).

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  • (His1223) exchange in the HD-PTP phosphotyrosine recognition loop results in the loss of π-π stacking interactions with the substrate.

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  • Gordon JA (1991) Use of vanadate as protein-phosphotyrosine phosphatase inhibitor.

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  • In contrast to alanine in that position, Ser1394 in HD-PTP does not form favorable substrate interactions with the bound phosphotyrosine.

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  • Zambrano N, Minopoli G, Donini V, Duilio A, et al. (1995) The regions of the Fe65 protein homologous to the phosphotyrosine interaction / phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein.

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  • Zambrano N, Buxbaum JD, Minopoli G, Fiore F, De Candia P, et al. (1997) Interaction of the phosphotyrosine interaction / phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins.

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  • FE65 is an adapter protein with a single WW domain and two phosphotyrosine binding (PTB) domains

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