from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A crystalline alkaloid, C15H21N3O2, extracted from the Calabar bean, used in medicine as a miotic and cholinergic agent and to enhance memory in patients with Alzheimer's disease. Also called eserine.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A parasympathomimetic, a reversible cholinesterase inhibitor alkaloid of the Calabar bean, used to treat certain medical conditions.
from the GNU version of the Collaborative International Dictionary of English
- n. An alkaloid found in the Calabar bean (the seed of Physostigma venenosum), and extracted as a white, tasteless, substance, amorphous or crystalline; -- formerly called eserine, with which it was regarded as identical.
from The Century Dictionary and Cyclopedia
- n. An alkaloid constituting the active principle of the Calabar bean.
- n. It is a powerful depressant and nerve-poison: used to counteract strychnine and atropin, also to contract the pupil. Its formula is C15H21O2N3. Also called eserine.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. used in treatment of Alzheimer's disease and glaucoma
He would see what happens to vervet monkeys every single month at Aberdeen Proving Ground in Maryland: in a crude simulation of a nerve agent attack, the monkeys are given a massive overdose of a drug called physostigmine.
In one form of chemical casualty management training, anesthetized primates are given a chemical called physostigmine, which simulates exposure to a nerve gas by causing cholinergic intoxication.
One report 252 states that IV physostigmine can do the same on a transient basis, but that finding cannot be applied to clinical practice at this time.
When an antidote such as physostigmine for anticholinergic toxicity to drug toxicity is not available, as is often the case, the clinician may need to wait several days or weeks for the condition to clear fully.
Anticholinergic delirium was diagnosed, all psychotropic medication was discontinued, subcutaneous physostigmine was administered, and she became essentially symptom-free within 48 hours.
Tricyclic antidepressant poisoning: Reversal of coma, choreoathetosis, and myoclonus by physostigmine.
Primary treatment is physostigmine, which readily crosses the blood-brain barrier and counters peripheral and central cholinergic blockade.
The reversal of anticholinergic drug-induced delirium and coma with physostigmine.
It responds to the central cholinesterase inhibitor, physostigmine (2 mg IV); the dosage may be repeated in 20 minutes and again in 30 minutes (145).
With the help of synthetic chemists, morphine has become hydromorphine; lysergic acid has been converted to methylysergide; cocaine has yielded procaine; physostigmine has been converted into neostigmine and salicin has been changed into acetylsalicylic acid.