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Examples
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Either knockdown of pirin or treatment with the small molecule inhibited melanoma cell migration.
Naturejobs - All Jobs Isao Miyazaki 2010
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Figure 1: Identification of TPh A as a pirin binder.
Naturejobs - All Jobs Isao Miyazaki 2010
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Figure 3: Inhibition of the interaction between pirin and Bcl3 by TPh A
Naturejobs - All Jobs Isao Miyazaki 2010
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Figure 2: Crystal structure of the complex formed by pirin and TPh A. Pirin is colored green and cyan for the N - and C-terminal regions, respectively.
Naturejobs - All Jobs Isao Miyazaki 2010
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Human pirin is a nuclear protein of unknown function that is widely expressed in punctate subnuclear structures in human tissues.
Naturejobs - All Jobs Isao Miyazaki 2010
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Figure 4: Inhibition of melanoma cell migration by TPh A. (a) Expression of pirin in human cell lines.
Naturejobs - All Jobs Isao Miyazaki 2010
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HEK293T cell lysates that overexpressed DsRed-fused pirin.
Naturejobs - All Jobs Isao Miyazaki 2010
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Thus, inhibition of pirin by the small molecule has led to
Naturejobs - All Jobs Isao Miyazaki 2010
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Here, we report the discovery of a small molecule that binds to pirin.
Naturejobs - All Jobs Isao Miyazaki 2010
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We determined how the small molecule bound to pirin by solving the cocrystal structure.
Naturejobs - All Jobs Isao Miyazaki 2010
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