Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A natural
antibiotic occurring in strains of Streptomyces platensis
Etymologies
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Examples
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TWO YEARS AGO, the discovery of an antibiotic called platensimycin, which blocks fatty acid synthesis in many human bacterial pathogens, inspired teams of researchers to focus on blocking lipid production as a new antimicrobial strategy.
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The discovery and characterization of new drugs targeting key enzymes involved in essential mycobacterial biosynthetic pathways is paramount but without the introduction of novel lead compounds, such as platensimycin antitubercular therapy will not proceed fast enough to cope with the increasing resistance observed today.
PLoS ONE Alerts: New Articles Alistair K. Brown et al. 2009
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Sifting through South African soil samples, scientists at Merck Research Laboratories found a new compound called platensimycin.
OpEdNews - Quicklink: A new compound fights drug-resistant bacteria 2008
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VIEW FAVORITES yahooBuzzArticleHeadline = 'A new compound fights drug-resistant bacteria '; yahooBuzzArticleSummary =' Sifting through South African soil samples, scientists at Merck Research Laboratories found a new compound called platensimycin.
OpEdNews - Quicklink: A new compound fights drug-resistant bacteria 2008
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To study the biochemical effects of platensimycin treatment, cultures of
PLoS ONE Alerts: New Articles Alistair K. Brown et al. 2009
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To test the antimycobacterial potency of platensimycin against slow growing mycobacteria we first tested the activity of the antibiotic against
PLoS ONE Alerts: New Articles Alistair K. Brown et al. 2009
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The team of researchers at Merck who initially reported platensimycin released a statement saying that the new results "are interesting, yet they represent an incomplete story due to the limited number of bacterial organisms and compounds that were studied in their in vivo work."
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The cell viability assay was carried out as per the manufacturer's protocol followed by MIC Determination of the in vivo effects of platensimycin on cell envelope lipid synthesis
PLoS ONE Alerts: New Articles Alistair K. Brown et al. 2009
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The study showed that, with access to lipids, bacteria could grow in the presence of two commercially available drugs that target fatty acid synthesis: cerulenin, which inhibits the same enzyme target as platensimycin, and triclosan.
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The model illustrates steric compatibility between platensimycin and the active site of Mt-KasB, but hints at subtle differences in protein-inhibitor interactions between Ec-FabF and Mt-KasB.
PLoS ONE Alerts: New Articles Alistair K. Brown et al. 2009
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