Definitions

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  • noun biochemistry A protein found in platelets

Etymologies

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Abbreviation of platelet + leukocyte C kinase substrate + KSTR amino acid string.

Examples

  • Interaction between the newly generated 3-phosphorylated phosphoinositides and distinct structural motifs, such as pleckstrin homology (PH) domain, can regulate the activity of different proteins through their membrane targeting or direct modulation of their enzymatic activity

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  • Sec3-N adopts a pleckstrin homology (PH) fold, despite having no detectable sequence homology with other PH domains of known structure.

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  • Phlda2 (pleckstrin homology-like domain, family A, member 2) was identified in C2

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  • These lipids bind to the pleckstrin homology (PH) domains of proteins such as PKB (Akt) and control the activity and subcellular localisation of a diverse array of signal transduction molecules

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  • Morozov P, Frank D, Musalo R, Lemmon MA, et al. (2002) Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1.

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  • Morozov P, Frank D, Musalo R, Lemmon MA, et al. (2002) Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1.

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  • Phlda2 (pleckstrin homology-like domain, family A, member 2) was identified in C2

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  • These lipids bind to the pleckstrin homology (PH) domains of proteins such as PKB (Akt) and control the activity and subcellular localisation of a diverse array of signal transduction molecules

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  • PDGF, platelet-derived growth factor; PDK1, 3-phosphoinositide-dependent protein kinase-1; PH, pleckstrin homology; PH-in, protein kinase B in an inactive conformation; PKB, protein kinase B Author Summary

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  • Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, et al. (2003) Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.

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