from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective anatomy Having several
from Wiktionary, Creative Commons Attribution/Share-Alike License
To assess whether the keratinocyte progeny of human embryonic stem cells (hESCs) could be used to form a temporary skin substitute for use in patients awaiting autologous grafts, we investigated the cells 'capability of constructing a pluristratified epidermis.
After seeding on an artificial matrix, keratinocytes derived from hESCs (K-hESCs) formed a pluristratified epidermis.
Interpretation hESCs can be differentiated into basal keratinocytes that are fully functional-ie, able to construct a pluristratified epidermis.
In vivo studies have demonstrated that p63 plays complex and pivotal roles in pluristratified squamous epithelial development, but its precise function and the nature of the isoform involved remain controversial.