from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry A protein which lines the podocytes and whose mutations can cause nephrotic syndrome


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  • Interaction with podocin and nephrin in the slit diaphragm was shown

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  • Lichtenberger A, Karle SM, Haas JP, Anacleto FE, et al. (2004) Patients with mutations in NPHS2 (podocin) do not respond to standard steroid treatment of nephrotic syndrome.

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  • The recent finding that podocin through cholesterol recruitment provides mechanosensitive properties to ion channels such as TRPC6, adds to the notion that the podocyte slit diaphragm relates information into podocyte foot processes

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  • TRPC6 is an essential component of the podocyte slit diaphragm, where it is integrated into a signaling complex that interacts with nephrin and podocin

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  • Gribouval O, Roselli S, Benessy F, Lee H, et al. (2000) NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome.

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  • Villegas G, Teichman J, Mundel P, Tufro A (2006) Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP.

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  • Homozygous or compound heterozygous mutations in the podocin gene NPHS2 are found in 10-30\% of pediatric cases of steroid resistant nephrosis and / or FSGS.

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  • Expression of NPHS2 (podocin), GSTA1 (Glutathione S-transferase α1), DUSP9 (Dual-specificity phosphatase 9), PTGER1 (Prostaglandin E receptor 1), KCNJ1 (Renal outer medullary potassium channel, ROMK1) and MUC1 (Mucin 1) in 60 normal samples was standardized either by the reference gene RPLP1 (blue points) or by SF (pink points).

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