podocyte

During the last decade, enormous advances have been made in the understanding of podocyte structure and function.

Naturejobs - All Jobs Jochen Reiser 2010

This mini-review discusses some of the most recent promising data related to potential drug therapy for proteinuria and kidney disease through direct podocyte targeting.

Naturejobs - All Jobs Jochen Reiser 2010

A role for novel cell-cycle proteins in podocyte biology

Naturejobs - All Jobs Peter M Price 2010

The glomerular podocyte is a highly specialized and polarized kidney cell type that contains major processes and foot processes that extend from the cell body.

Elites TV 2009

TRPC6 is an essential component of the podocyte slit diaphragm, where it is integrated into a signaling complex that interacts with nephrin and podocin

PLoS ONE Alerts: New Articles Saskia F. Heeringa et al. 2009

Monogenic disease genes of NS code for proteins that are essential for nephron development and an intact podocyte slit diaphragm

PLoS ONE Alerts: New Articles Saskia F. Heeringa et al. 2009

Multiple TRP channel family members have been reported to be involved in mechanosensation, and altered TRPC6 channel function could influence podocyte sense for flow, stretch or pressure, thereby in turn affecting the reorganization of the podocyte actin cytoskeleton in response to physiological changes

PLoS ONE Alerts: New Articles Saskia F. Heeringa et al. 2009

Impaired cytoskeletal reorganization could be envisioned as a result of defective mechanosensation (e.g. through hyperactive TRPC6), which in turn leads to podocyte damage, podocyte loss and, ultimately, FSGS.

PLoS ONE Alerts: New Articles Saskia F. Heeringa et al. 2009

The recent finding that podocin through cholesterol recruitment provides mechanosensitive properties to ion channels such as TRPC6, adds to the notion that the podocyte slit diaphragm relates information into podocyte foot processes

PLoS ONE Alerts: New Articles Saskia F. Heeringa et al. 2009

[These] findings support a causal role for induction of the matricellular protein SPARC in mediating podocyte loss, thereby accelerating [kidney] injury. "

EurekAlert! - Breaking News 2009