from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. Any of a group of organic compounds, such as spermine and spermidine, composed of only carbon, nitrogen, and hydrogen and containing two or more amino groups.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. any compound having many (more than three) amino functional groups; especially such compounds formed by decomposition of proteins


from Wiktionary, Creative Commons Attribution/Share-Alike License

From poly- +‎ amine


  • The organic compound spermidine is a polyamine and is found in all living cells.

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  • Synthesis and biological evaluation of polyamine toxins as tools for studies of ionotropic glutamate receptors.

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  • Polyamines are associated with cell growth and cancer development, and previous research has shown that a polyamine-inhibiting regimen of difluoromethylornithine (DFMO) plus sulindac

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  • Researchers found that patients with the highest dietary polyamine intake were more likely to have colorectal adenomas greater than 1 cm and advanced adenomas, compared to those with the lowest dietary polyamine intake

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  • They conclude that control of dietary intake of polyamines may be an effective adjunctive strategy to polyamine inhibitors for preventing colorectal adenomas and cancer

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  • However, they found that DFMO/sulindac treatment only reduced adenoma risk among patients with lower intake of dietary polyamines, and not among those with higher dietary polyamine intake.

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  • Hence, iNOS may down-regulate proline and polyamine production in M1 MØ by competing with Arg II for L-Arg.

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  • Li H, Meininger CJ, Hawker JR Jr, Haynes TE, Kepka-Lenhart D, et al. (2001) Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells.

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  • Presentation Title: Novel oligoamine / polyamine analogues inhibit lysine-specific demethylase 1 (LSD1), induce re-expression of epigenetically silenced genes, and inhibit the growth of established human tumors in vivo News Articles

  • LAD2 (A, C) and primary human MCs (B, D) were cultured in polyamine-free medium and sensitized overnight with human myeloma IgE.

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