Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective genetics Describing
mRNA thatencodes for multiple differentpolypeptides
Etymologies
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Examples
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Among others, many prokaryotic messages are polycistronic, few eukaryotic.
Uncommonly Dense blows common descent. - The Panda's Thumb 2007
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The strategy of these authors entailed the introduction of a polycistronic vector encoding the genes c-Myc, Klf4, and SV40LT and selection of stable episomes that provided persistent gene expression to achieve reprogramming followed by the identification of vector-free subclones after several passages in the absence of selection.
BioMed Central - Latest articles Cesar Sommer 2010
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We find mir-424 and mir-503 are derived from a polycistronic precursor mir-424-503 that is under repression by the MLL-MLLT3 leukemogenic fusion.
Naturejobs - All Jobs A R R Forrest 2010
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Stem Cell Cassette (STEMCCA) polycistronic lentiviral vector
BioMed Central - Latest articles Cesar Sommer 2010
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We find mir-424 and mir-503 are derived from a polycistronic precursor mir-424-503 that is under repression by the MLL-MLLT3 leukemogenic fusion.
Naturejobs - All Jobs A R R Forrest 2010
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A feasible way to decrease the risk of insertional mutagenesis is to combine the reprogramming factors into a single polycistronic vector by inserting a 'self-cleaving' 2A peptide or an internal ribosome entry site (IRES) sequence between two consecutive open reading frames.
BioMed Central - Latest articles Cesar Sommer 2010
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Similarly, a Cre-expressing plasmid or adenovirus was employed to remove three or four copies of a polycistronic vector from the genome of mouse iPSCs
BioMed Central - Latest articles Cesar Sommer 2010
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Notably, these studies demonstrated that somatic cells carrying a single proviral copy of the polycistronic cassette can be reprogrammed to pluripotency, substantially reducing genomic modification of the target cell.
BioMed Central - Latest articles Cesar Sommer 2010
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A number of studies have recently demonstrated the advantage of using polycistronic vectors for iPSC generation.
BioMed Central - Latest articles Cesar Sommer 2010
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Alternative initiation strategies by ribosomal frameshifting and leaky scanning enable polycistronic translation of the cap-dependent viral transcript.
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