Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • adjective genetics Describing mRNA that encodes for multiple different polypeptides

Etymologies

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Examples

  • Among others, many prokaryotic messages are polycistronic, few eukaryotic.

    Uncommonly Dense blows common descent. - The Panda's Thumb

  • The strategy of these authors entailed the introduction of a polycistronic vector encoding the genes c-Myc, Klf4, and SV40LT and selection of stable episomes that provided persistent gene expression to achieve reprogramming followed by the identification of vector-free subclones after several passages in the absence of selection.

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  • We find mir-424 and mir-503 are derived from a polycistronic precursor mir-424-503 that is under repression by the MLL-MLLT3 leukemogenic fusion.

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  • Stem Cell Cassette (STEMCCA) polycistronic lentiviral vector

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  • We find mir-424 and mir-503 are derived from a polycistronic precursor mir-424-503 that is under repression by the MLL-MLLT3 leukemogenic fusion.

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  • A feasible way to decrease the risk of insertional mutagenesis is to combine the reprogramming factors into a single polycistronic vector by inserting a 'self-cleaving' 2A peptide or an internal ribosome entry site (IRES) sequence between two consecutive open reading frames.

    BioMed Central - Latest articles

  • Similarly, a Cre-expressing plasmid or adenovirus was employed to remove three or four copies of a polycistronic vector from the genome of mouse iPSCs

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  • Notably, these studies demonstrated that somatic cells carrying a single proviral copy of the polycistronic cassette can be reprogrammed to pluripotency, substantially reducing genomic modification of the target cell.

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  • A number of studies have recently demonstrated the advantage of using polycistronic vectors for iPSC generation.

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  • Alternative initiation strategies by ribosomal frameshifting and leaky scanning enable polycistronic translation of the cap-dependent viral transcript.

    BioMed Central - Latest articles

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