from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A small form of the
papovavirusthat causes tumorsin rodents.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a virus the can initiate various kinds of tumors in mice
Sorry, no etymologies found.
Because of these widely various neoplastic effects it has been aptly termed the polyoma virus.
Working on a small oncogenic DNA virus, polyoma, I could show there, with I. Macpherson, a new property of transformed cells, that of growing in soft agar.
Using this technique, it was easy to detect the transforming capacity of polyoma virus and its DNA.
In collaboration with my colleague Jörg Schlehofer, we were also able to demonstrate that herpes simplex virus, but also other herpes -, adeno -, and vaccinia virus infections of polyoma - or papillomavirus DNA harbouring cells, resulted in amplification of the DNA of the latter.
One came up this year only – the so-called Merkel cell carcinoma polyoma virus, which – the virus is called Merkel cell polyoma virus – which has been found in Merkel cell carcinomas, and every evidence at this stage points to the fact that this is indeed aetiologically involved.
Last May, David Wang of Washington University School of Medicine in St. Louis discovered the WU virus, a new type of polyoma virus that may be causing respiratory infections and perhaps other problems.
During that period I spent about half my time working on polyoma virus infected cells, the main research program of the laboratory, and about half the time trying to get something of my own started.
We used it to show that polyoma infected cells induced cellular DNA synthesis and a complement of cellular DNA replication enzymes.
The first results, crucial for future developments, showed that polyoma virus could be assayed in certain cell cultures (1), which we call permissive, and could induce a cancer-like state in other cultures (2, 3) in which the virus does not grow, which we call non-permissive.
Within a short time polyoma virus became the main interest of my laboratory, to be joined, a few years later by SV40, another papovavirus.
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