from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A
drugused to treat equine protozoalmyeloencephalitis in horses.
Sorry, no etymologies found.
"Based on reported side effects, ponazuril and diclazuril seem to have the fewest reported adverse effects."
She explained that sulfadiazine/pyrimethamine combination (Rebalance), ponazuril (Marquis), and nitazoxanide (Navigator) medications are the approved treatments that have been commercially available, while diclazuril is approved for EPM treatment, but is not yet marketed.
Recent research has investigated one more option, Johnson reported -- that of toltrazuril sulfone or ponazuril given at a loading dose along with dimethyl sulfoxide (DMSO) to improve uptake of the medications.
Diclazuril's mode of action is unknown, but might be similar to that of the related medication ponazuril; it is also given for 28 days.
For example, shipping stress is a known risk factor for development of EPM, and pretreatment with ponazuril prior to -- and during -- periods of similar stress might decrease the risk of disease.
Pretreatment of horses with ponazuril has been shown to decrease the risk of infection with
Diclazuril, a very similar compound to ponazuril, has received FDA approval, but it has not been released by the company as of this writing.