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Examples
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For his PhD thesis, "Strategies for the comparative genomic study of microorganisms with various levels of pregenomic information and genic complexity", Dr Lavin used an emerging discipline: bioinformatics.
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In cell culture, the binding of hepatocyte nuclear factor 4α (HNF4α) or retinoid X receptor α (RXRα) plus peroxisome proliferator-activated receptor α (PPARα) to the nucleocapsid promoter regulatory elements governs the level of synthesis of this critical HBV pregenomic 3. 5kb RNA template
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HBV replicates its genomic DNA by reverse transcription of a pregenomic 3. 5kb RNA which is transcribed from covalently closed circular
PLoS ONE Alerts: New Articles Lie Li et al. 2009
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The lower levels of viral 3. 5kb pregenomic RNA associated with diminished HNF4α abundance in the liver resulted in similarly reduced HBV replication (
PLoS ONE Alerts: New Articles Lie Li et al. 2009
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