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Examples
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In the initial phase of NMJ formation, nicotinic acetylcholine receptors (AChRs) cluster with other postsynaptic proteins in the central regions of the myofibers after myogenesis independently of innervations by motor neurons; this process is called "prepatterning"
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Moreover, preferential expression of the AChR α and ephrin-A5 genes in the synaptic region of muscles was disrupted in meltrin β − / − mice, whereas the expression pattern of the MuSK gene, a key player for the prepatterning of the NMJ, was not affected in these mice.
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In contrast to the molecular mechanisms of prepatterning of the NMJ postsynaptic regions, the factors produced by muscles to differentiate presynaptic specializations have been poorly understood.
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Consistent with this idea, Meltrin β gradually localizes to the NMJ during the late stage of embryogenesis, after the establishment of prepatterning in muscles and initial axon pathfinding although Meltrin β is expressed in the ventral horn of the spinal cord already at E12. 5.
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These phenotypes suggest that Meltrin β does not participate in the prepatterning of the NMJ but mediates the stabilization of the NMJ through the fine-tuning of terminal axon branching and / or the transcriptional confinement of some post-synaptic genes.
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