from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A potent antineoplastic drug, C12H19N3O, used primarily to treat advanced Hodgkin's disease.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A particular drug used in chemotherapy.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. an antineoplastic drug used to treat Hodgkin's disease
For the past decade, a modified chemotherapy regimen consisting of cyclophosphamide, vincristine, procarbazine and prednisone (COPP), together with adriamycin, bleomycin and vinblastine (ABV) has been used to treat patients with HD.
This modified regimen contained less cyclophosphamide and procarbazine, agents known to impair fertility.
Methotrexate was substituted with a more powerful agent, procarbazine, and the duration of treatment was lengthened from two and a half months to six months.
On one side of the board was a list of cytotoxic drugs—Cytoxan, vincristine, procarbazine, methotrexate.
Alliance says that combined sales of ImmuCyst, Gelclair, and procarbazine represent some 40% of Cambridge Labs total sales in 2009.
These include: ImmuCyst®, an immunotherapy for superficial bladder cancer; Gelclair®, an oral gel for managing oral mucositis in chemotherapy patients; and the Hodgkin lymphoma therapy procarbazine.
This trial compared the following regimens: doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) for 6 to 8 months, mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) for 6 to 8 months, and MOPP alternating with ABVD for 12 months. 1 The trial was limited to patients with advanced disease (clinical stages III and IV).
The study of 401 patients found that a regimen of thioguanine, procarbazine, lomustine and vincristine (TPCV) was more effective than a carboplatin and vincristine (VC) regimen and achieved a 5-year, event-free survival rate of almost 50 percent.
However, the COG trial with 401 patients enrolled, showed that a thioguanine, procarbazine, lomustine and vincristine (TPCV) regimen was more effective than the CV regimen and resulted in a five-year event-free survival rate of nearly