Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Plural form of
promyelocyte .
Etymologies
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Examples
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In APL, an abnormal accumulation of immature granulocytes called promyelocytes in the bone marrow results in a reduction in the production of normal red blood cells and platelets, resulting in anemia and thrombocytopenia.
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Normal promyelocytes are loaded with toxic enzymes and granules that are usually released by adult white blood cells to kill viruses, bacteria, and parasites.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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This created an activated “chimeric” oncogene that drove the proliferation of promyelocytes and blocked their maturation, thus creating the peculiar syndrome of APL.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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Normal promyelocytes are loaded with toxic enzymes and granules that are usually released by adult white blood cells to kill viruses, bacteria, and parasites.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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In promyelocytic leukemia, the blood fills up with these toxin-loaded promyelocytes.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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APL is characterized by the malignant proliferation of these immature promyelocytes.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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In some patients, the differentiation and death erupted so volcanically that the bone marrow swelled up with differentiated promyelocytes and then emptied slowly over weeks as the cancer cells matured and underwent an accelerated cycle of death.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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Leukemic promyelocytes in the blood underwent a brisk maturation into white blood cells.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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In promyelocytic leukemia, the blood fills up with these toxin-loaded promyelocytes.
The Emperor of All Maladies Siddhartha Mukherjee 2010
-
This created an activated “chimeric” oncogene that drove the proliferation of promyelocytes and blocked their maturation, thus creating the peculiar syndrome of APL.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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