Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun pathology Any
impairment ofcell function caused bymisfolding of aprotein
Etymologies
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Examples
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Many diseases of aging, including Alzheimer's disease and various forms of Parkinsonism, are associated with proteotoxicity caused by improper folding and aggregation of proteins.
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Human HSF1 is normally activated by cellular stress conditions that cause proteotoxicity through protein damage.
PLoS Biology: New Articles Daniel W. Neef et al. 2010
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Although there is no known cure for these devastating diseases, the ability to stabilize misfolded proteins into their native conformation would likely prevent the neuronal proteotoxicity that is observed in Huntington disease and other protein conformational disorders.
PLoS Biology: New Articles Daniel W. Neef et al. 2010
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Many diseases of aging, including Alzheimer's disease and various forms of Parkinsonism, are associated with proteotoxicity caused by improper folding and aggregation of proteins.
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Thus, when Neef, Turski, and Thiele set out to identify small molecules that would activate human HSF1 from a library of over 10,000 compounds, they designed their screen to be insensitive to compounds that promoted proteotoxicity or inhibited Hsp90.
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Project 1: Modeling age-dependent proteotoxicity in adult Drosophila
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Salubrinal further aggravated ER-stress and proteotoxicity inflicted by the proteasome inhibitors on the leukemic cells since characteristic ER stress responses, such as ATF4 and CHOP synthesis, XBP1 splicing, activation of MAP kinases and eventually apoptosis were efficiently abrogated by the translational inhibitor cycloheximide.
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Dillin A (2008) The insulin paradox: aging, proteotoxicity and neurodegeneration.
PLoS ONE Alerts: New Articles Greg T. Sutherland et al. 2009
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Many diseases of aging, including Alzheimer's disease and various forms of Parkinsonism, are associated with proteotoxicity caused by improper folding and aggregation of proteins.
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[32], [33] and it has recently been suggested that excessive IGF1 signaling accelerates ageing through deleteriously effects on protective mechanisms against proteotoxicity such as Lewy body formation in PD
PLoS ONE Alerts: New Articles Greg T. Sutherland et al. 2009
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