proviral

I myself, with P. Vigier, confirmed and extended this discovery by showing that the infectious DNA was associated with the chromosomal DNA of the cells, showing integration of the proviral DNA, as earlier postulated by Temin.

Luc Montagnier - Autobiography 2009

Robertson, E.J. The ability of EK cells to form chimaeras after selection of clones in G418 and some observations on the integration of retroviral vector proviral DNA into EK cells.

The 2007 Nobel Prize in Physiology or Medicine - Advanced Information 2007

We estimate that there are about 140 proviral loci or remains of such per haploid genome.

Uncommon Despair - The Panda's Thumb 2007

During an epidemic of some exogenous retrovirus, retroviruses may be able to enter the germline, lose their ability to be transmitted through infection, and become fully endogenous – being preserved from generation to generation in the genome in proviral DNA form.

The Last Universal Common Ancestor - The Panda's Thumb 2005

Despite the fact that viral vectors have proven to be effective tools for reprogramming, the resulting iPSC clones usually display several proviral integrations, ultimately increasing the risk of insertional mutagenesis.

BioMed Central - Latest articles Cesar Sommer 2010

The possibility of deriving iPSCs with single proviral integrations has stimulated the development of methodologies aimed at removing the transgenes by Cre/loxP technology.

BioMed Central - Latest articles Cesar Sommer 2010

For amplification of proviral HIV-1 env gene, genomic DNA was extracted from uncultured peripheral blood mononuclear cells (PBMC) using the Puregene kit (Gentra Systems) for all subjects except mother 1084.

PLoS ONE Alerts: New Articles Hong Zhang et al. 2010

TARmiR was able to inhibit HIV gene expression as a TAR decoy and by RNA interference when challenged with infectious proviral DNA.

BioMed Central - Latest articles Hoshang Unwalla 2010

TARmiR was able to inhibit HIV gene expression as a TAR decoy and by RNA interference when challenged with infectious proviral DNA.

BioMed Central - Latest articles Hoshang Unwalla 2010

Notably, these studies demonstrated that somatic cells carrying a single proviral copy of the polycistronic cassette can be reprogrammed to pluripotency, substantially reducing genomic modification of the target cell.

BioMed Central - Latest articles Cesar Sommer 2010