Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A potent folic acid antagonist, C12H13ClN4, used as a prophylactic antimalarial agent against Plasmodium falciparum and in the treatment of toxoplasmosis.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun medicine a
folic acid antagonist , used in theprophylactic treatment ofmalaria
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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Behe actually spends a lot of time discussing cumulative resistance, for example Malarial resistance to pyrimethamine.
Behe Responds 2007
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Prophylaxis in Pregnancy: In endemic areas where prenatal care exists, giving pregnant women sulfadoxine-pyrimethamine (SP) in the latter part of pregnancy can reduce anemia-related deaths and low birthweight.
Fighting Malaria - The Time is Now aka TBTAM 2007
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The Centers for Disease Control estimates average treatment costs of only 13 cents for chloroquine, 14 cents for sulfadoxine-pyrimethamine, and $2.68 for a seven-day course of quinine.
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One set of treatments that was developed to take the place of chloroquine is abbreviated S/P, which stands for two different drugs, sulfadoxine with pyrimethamine.
The Edge of Evolution Michael J. Behe 2007
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Apparently, as for the case of chloroquine resistance, a very lucky malarial cell in one infected person acquired the several changes that gave it greater resistance to pyrimethamine while compensating for any bad side effects.
The Edge of Evolution Michael J. Behe 2007
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Nearly all sub-Saharan African countries have switched their national drug policies to phase out old drugs (chloroquine and sulfadoxine-pyrimethamine) that have become useless through resistance and replace them with artemisinin-based combination therapies (ACT), said the report.
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The authors point out that S/P should not be considered a drug combination because the sulfadoxine and pyrimethamine must act synergistically.
The Edge of Evolution Michael J. Behe 2007
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The authors point out that S/P should not be considered a drug combination because the sulfadoxine and pyrimethamine must act synergistically.
The Edge of Evolution Michael J. Behe 2007
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Because resistance to pyrimethamine can be conferred by a single point mutation, it was assumed that resistance could occur frequently.
The Edge of Evolution Michael J. Behe 2007
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In the case of pyrimethamine the “P” in the “S/P”, the drug interferes with an enzyme abbreviated DHFR.
The Edge of Evolution Michael J. Behe 2007
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