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- adjective genetics Of or pertaining to genetic
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Renilla and firefly luciferase genes to create pcDNA3. 1-hODC-IRES. pcDNA3. 1-V5-ZNF9 was constructed by insertion of the PCR-generated full-length open reading frame of human ZNF9 into pENTR and subsequent recombination into pcDNA3. 1/nV5-Dest (Invitrogen) by recombinational cloning (Invitrogen).
Germline mutations in a number of genes involved in the recombinational repair of DNA double-strand breaks are associated with predisposition to breast and ovarian cancer.
However the divergence between the strains was such that it was difficult to consistently distinguish mutational and recombinational SNPs, as the frequency of mutations was higher so that putative recombinant segments were not easily distinguished.
In addition, sequences at the genomic termini were believed to be recombinational hot-spots due to the induction of an additional double-strand break mechanism or due to the high GC content at the DNA ends
Fasullo MT, Davis RW (1988) Direction of chromosome rearrangements in Saccharomyces cerevisiae by use of his3 recombinational substrates.
Wolner B, van Komen S, Sung P, Peterson CL (2003) Recruitment of the recombinational repair machinery to a DNA double-strand break in yeast.
Decreased translocation formation by recombinational repair of double-strand breaks in telomerase-deficient yeast suggests that the reemergence of telomerase expression observed in many human tumors may further stimulate genome rearrangement.